Vol. 13. Núm. 56.
Páginas 3322-3326 (Mayo 2022)

Protocolos de práctica asistencial
Indicaciones para la prevención de infecciones en el paciente inmunocomprometido

Indications for infection prevention in immunocompromised patients

R. Falcón AbadA. Pérez-GarcíaM. Íñigo Pestaña
Doi : https://10.1016/j.med.2022.05.017
Opciones
Resumen

El 48%-60% de los pacientes inmunosuprimidos pueden sufrir un episodio febril, fiebre o una infección establecida u oculta; sin embargo, el uso de antibióticos como medida profiláctica sigue siendo una medida controvertida, debido al preocupante aumento de las resistencias bacterianas, las alteraciones que se producen en la microbiota del huésped o las interacciones farmacológicas que pueden producir. Las recomendaciones europeas y americanas coinciden en la elección de las fluoroquinolonas como profilaxis en pacientes inmunosuprimidos con una neutropenia de más de 7 días de duración. Además de una estrategia profiláctica eficaz, es fundamental un diagnóstico precoz para un rápido tratamiento efectivo.

Palabras clave
Profilaxis
Fluroroquinolonas
Neutropenia
Abstract

A total of 48% to 60% of immunosuppressed patients may have a febrile episode, fever, or established or hidden infection. However, the use of antibiotics as a prophylactic measure continues to be controversial due to the worrying rise in bacterial resistance, changes that occur in the host's microbiota, and drug interactions they may cause. European and American recommendations agree on the choice of fluoroquinolones as prophylaxis in immunosuppressed patients with neutropenia that has been ongoing for more than seven days. In addition to an effective prophylaxis strategy, early diagnosis is fundamental for rapid, effective treatment.

Keywords
Prophylaxis
Fluoroquinolones
Neutropenia

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