TY - JOUR T1 - Canalopatías JO - Medicine VL - 11 IS - 39 PY - 2013 T2 - AU - Gallego, A. Macías AU - García, A. Vázquez SN - 03045412 M3 - 10.1016/S0304-5412(13)70629-2 DO - 10.1016/S0304-5412(13)70629-2 UR - https://medicineonline.eshttps://medicineonline.es/en-canalopatias-articulo-S0304541213706292 AB - Channelopathies are rare arrhythmic disorders, congenital and inherited, often resulting from a mutation or mutations in the genes encoding cardiac ion-channels proteins. The high prevalence of malignant ventricular arrhythmias is the common denominator. Cardiac channelopathies are the major causes of sudden death. Sudden death (SD) is defined as death occurring within 1 hour of onset of symptoms in a person with or without pre-existing heart disease, secondary to Ventricular Tachycardia (VT), Ventricular Fibrillation (VF), asystole or non-arrhythmic causes. It is a first rate problem affecting between three and five million people annually. Ischemic heart disease is the major cause of SD, in both acute and chronic form, and it is the first clinical manifestation of the disease in one third of patients. Channelopathies affect mainly sodium, potassium or calcium channels and they are responsible for 5–10% of cases of SD. The principal channelopathies are: Brugada syndrome, long QT syndrome, short QT syndrome and catecholaminergic polymorphic ventricular tachycardia. Electrocardiography is the most useful and simple tool for the diagnosis. Early transfer of patients to Arrhythmia Unit may allow a risk stratification and the appropriate therapeutic measures. KW - Channelopathies KW - Gentetics KW - Sudden death KW - Ventricular arrhythmias ER -